Not recommended in patients w/ ischemic heart disease or CHF. Severe hypersensitivity reactions, including DRESS were associated w/ fever, hematological, renal or hepatic involvement may occur; discontinue immediately if serious allergic/hypersensitivity reactions, including SJS occurs; must not be re-started in this patient at any time. Acute gouty attacks (gout flare). Patients in whom the rate of urate formation is greatly increased (eg, malignant disease & its treatment, Lesch-Nyhan syndrome) the absolute conc of xanthine in urine could rise sufficiently to allow deposition in the urinary tract. Concomitant treatment w/ mercaptopurine/azathioprine. Organ transplant recipients. LFT is recommended prior to the initiation of therapy & periodically thereafter. Patients w/ alteration of thyroid function; may increase TSH values in long-term use. Do not give in patients w/ rare hereditary problems of galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption. May affect the ability to drive & use machines. Do not use during pregnancy & while breastfeeding.
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